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Es sistmica, mortal en 5 % de los casos. Se diagnostica con biopsia de piel. No hay tratamiento especfico. Los sntomas comienzan luego de 1-2 meses de la exposicin. Fue recientemente asociada a la administracin endovenosa de gadolinio. UZUT  Objetivos _Conocer esta patologa y factores de riesgo. Informar las formas farmacuticas de menor riesgo.``Formas Farmaceticas Asociadas(  Los casos reportados fueron producidos por: El 90% luego de la inyeccin de: Gadodiamida (Omniscan). El 10 % luego de la inyeccin de: Gadoversetamida (Optimark) Gadopentetato de dimeglumina (Magnevist). dMZZ#ZJZM#JN   (          Formas Farmaceticas Seguras  No han sido reportados casos hasta marzo 2007 con: Gadoterato Meglumina (Dotarem), Gadobenato de dimeglumina (Multihance) Gadobutrol (Gadovist) Gadofosveset (Vasovist) Gadoxetato disdico (Primovist)..5545                     Factores DesencadenantesPresencia de insuficiencia renal crnica o aguda. Contraste con Gadodiamida (Omniscan). Dosis inyectada. Presencia de factores de inflamacin (ciruga prxima, coagulopatas, trombosis vasculares, sndromes inflamatorios).dA     . 2 Importancia de la funcin renal En insuficiencia renal grave ( clearence menor 30 ml/min/1,73m2): el riesgo es de 4,3 %. (IC al 95% de 1,3-7.3%). Asciende a 12,1 % al administrar dosis dobles. No han sido reportados casos en pacientes con funcin renal normal.HBZ`ZEZB`Ej    !  k   Imgenes      Imgenes     Imgenes      Conclusin En insuficiencia renal grave deberan valorares los beneficios / riesgos del estudio con gadolinio y, de ser necesario, usar las formas farmacuticas que no han sido asociadas.  Bibliografa The International Center for Nephrogenic Fibrosing Dermopathy Research (ICNFDR):http://www.pathmax.com/dermweb/ Nephrogenic Systemic Fibrosis: a serious late adverse reaction to gadodiamide. Eur Radiol (2006) 16: 2619-2621). Gadodiamide-Associated Nephrogenic Fibrosis: Why radiologists should be concerned. 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